Losartan相关论文
Losartan,aselectiveantagonistofAT1receptor,attenuatesacutelunginjuryinducedbyseawateri
目的 LosartanisaselectiveantagonistofAngItype(AT1)receptorofAngiotensinⅡ(AngⅡ),whichiswidelyusedasaclinicalmedicinefor......
Angiotensin Ⅱ type 2 receptor correlates to therapeutic effects of losartan on rats with adjuvant-in
Aim: Angiotensin Ⅱ type 1 receptor (AT1R) blocker losartan ameliorates the rheumatoid arthritis (RA) experimental model......
Angiotensin Ⅱ type 2 receptor correlates to therapeutic effects of losartan on rats with adjuvant-in
Aim: Angiotensin Ⅱ type 1 receptor (AT1R) blocker losartan ameliorates the rheumatoid arthritis (RA) experimental model......
Pharmacokinetic parameters of losartan and losartan/hydrochlorothiazide tablets in healthy chinese m
OBJECTIVE To evaluate and compare the of Losartan and Losartan/Hydrochlorothiaside combination tablets in healthy chinse......
Two different sources of ROS in paraventricular nucleus contribute to hypertension induced by chroni
Background & Objectives: Uncoupled neuronal nitric oxide synthase(nNOS)is the important resource of reactive oxygen spec......
Aim: To evaluate the intraocular pressure (IOP) lowering effect of losartan potassium in rats with steroid-induced ocula......
Aim: Angiotensin converting enzyme inhibitors and angiotensin Ⅱ receptor blockers are currently attractive as potential......
Oculohypotensive effect of topical losartan potassium in ocular normotensive and steroid-induced ocu
Aim: Systemically administered angiotensin Ⅱ receptor blocker, losartan, has been shown to reduce intraocular pressure ......
Objective To study the impacts of losartan and angiotensin Ⅱ (AngⅡ) towards the matrix metalloproteinase-9 (MMP-9) and......
目的：观察阻断血管紧张素Ⅱ (angiotensin Ⅱ,Ang Ⅱ)1型受体(type 1 receptor, AT1R)对创面愈合过程的创面愈合率以及创伤局部细胞......
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Effect of high glucose, angiotensin Ⅱ and receptor antagonist Losartan on the expression of connecti
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目的通过观察Losartan对实验动物性糖尿病大鼠血清、肾组织匀浆一氧化氮（nitricoxide，No）、血浆内皮素（endothcinEF）水平，初步探讨对肾脏......
洛萨坦(Losartan)可以保护糖尿病患者免于因心律失常而发生突然心源性死亡,其效果要好于阿坦洛(Atenolol)。 瑞典Ume大学医院的Dr......
The role of B7-1 in podocyte injury has received increasing attention.The aim of this study was to investigate whether l......
Protective Effects of Blocking Renin-Angiotensin System on the Progression of Renal Injury in Glomer
To investigate the protective effects of blocking rennin-angiotensin system (RAS) on the progression of renal injury in ......
目的 观察二氯沙坦/氢氯噻嗪治疗原发性高血压合并高尿酸血症的疗效与安全性.方法 选择178例原发性高血压合并高尿酸血症患者,随机......
目的评价骨化三醇联合氯沙坦治疗Ⅲ期和Ⅳ期早期糖尿病肾病的疗效评价。方法选取符合入组条件的47例患者,随机表分配入组到以下各......
目的探讨氯沙坦联合阿托伐他汀治疗原发性高血压的临床疗效及对血浆高敏C反应蛋白(hs-CRP)、内皮素(ET)和一氧化氮(NO)水平的影响......
目的观察氯沙坦联合前列腺素E1治疗早期糖尿病肾病的短期及远期疗效以及安全性。方法117例早期糖尿病肾病患者，按数字表法随机分组......
目的分析氯沙坦与氨氯地平对肥胖高血压患者的瘦素、脂联素及胰岛素敏感性方面的影响。方法选择肥胖高血压患者126例，按照随机数字......
目的探讨氯沙坦联合前列腺素 E1对早期糖尿病肾病(DN)患者的临床治疗效果.方法将106例早期 DN 患者随机分为研究组58例和对照组58......
目的：观察拉西地平联合氯沙坦治疗老年性高血压的临床疗效。方法选择老年高血压患者110例,随机等分为对照组(采用氯沙坦单一药物治......
目的研究腹主动脉结扎诱发大鼠肥厚心肌L-型钙电流的变化以及用氯沙坦治疗对此变化的影响.方法用结扎腹主动脉的方法诱发大鼠心肌......
Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: A p
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Effects of angiotensin Ⅱ receptor antagonist, Losartan on the apoptosis, proliferation and migration
AIM: To investigate the effects of AT1 (Type 1 angiotensin Ⅱ receptor) antagonist (Losartan) on the apoptosis,prolifera......
Inhibitory effect of angiotensin TT receptor antagonist on hepatic stellate cell activation in non-a
AIM: To investigate the efficacy of angiotensin Ⅱ receptor antagonist on hepatic stellate cells (HSCs) activation in th......
Study on the Effects of Losartan on Cardiomyocyte Apoptosis and Gene Expression After Ischemia and R
In order to study the effects of losartan on cardiomyocyte apoptosis following ischemia (0.5 h) and reperfusion (48 h) i......
Assessment of Effect of Angiotensin Ⅱ Receptor Antagonist Losartan on Aortic Distensibility in Patie
Summary: The effects of angiotensin Ⅱ receptor antagonist losartan on elastic properties of aorta in patients with mild......
目的 观察氯沙坦联合双氢克尿噻治疗原发性高血压的疗效及安全性.方法 40例原发性高血压患者,每天服氯沙坦50 mg、双氢克尿噻12.5 ......
Study on the Effects of Losartan on Cardiomyocyte Apoptosis and Gene Expression After Ischemia and R
In order to study the effects of losartan on cardiomyocyte apoptosis following ischemia (0.5 h) and reperfusion (48 h) i......
目的：探讨氯沙坦对老年高血压患者的降压和降尿酸作用。方法将120例高血压合并高尿酸血症患者随机分为氯沙坦组（n=60)和卡托普利组（n=......
目的 观察血管紧张素Ⅱ受体拮抗剂洛沙坦对大鼠单侧输尿管梗阻(UUO)模型肾间质纤维化的影响,探讨大剂量能否优于常规剂量起到更多......
目的 观察长期口服氯沙坦对高血压伴心房纤颤(房颤)患者脑卒中一级预防的效果.方法 采用前瞻性随机对照研究方法,将180例高血压伴......
在Langendorff灌注大鼠心脏模型上，观察了血管紧张素任预处理对心肌缺血再灌注损伤的作用，及其受体阻断剂Losartan对心肌缺血预处理......
观察心肌局部肾素－血管紧张素系统（ＲＡＳ）在心肌缺血再灌注损伤时的激活情况及特异性非肽类血管紧张素Ⅱ１型受体（ＡＴ１）阻断剂Ｌｏｓａｒｔａｎ的保护效应。方法离体......
Losartan (5mg·kg~(-1)·d~(-1)po)和卡托普利(50 mg·kg~(-1)·d~(-1)po)治疗肾性高血压大鼠8周均能在降压的同时降低左室重量34......
血管紧张素Ⅱ(ANG Ⅱ)是肾素-血管紧张素系统(RAS)中重要的介质,它作用于特异性受体,导致血管收缩和醛固酮的释放。Losartan是一种......
Ｌｏｓａｒｔａｎ较之其它抗高血压药物的安全性和耐受性评价［ＧｏｌｄｂｅｒｇＡＩ，ＤｕｎｌａｙＭＣ，ＳｗｅｅｔＣＳ．ＡｍＪＣａｒｄｉｏｌ，１９９５，７５：７９３（英文）］Ｌｏｓａｒｔａｎ是新一类口服活性非肽型血管紧张素Ⅱ受体拮抗剂的代表性药物。本文就其...
Evalu......
默克公司上市１００ｍｇｌｏｓａｒｔａｎ片剂据《Ｓｃｒｉｐ》报道：默克公司的一种血管紧张素Ⅱ拮抗剂ｌｏｓａｒｔａｎ（商品名Ｃｏｚａａｒ）的１００ｍｇ新制剂已在它的第１个市场加拿大上市。该药的２５ｍｇ和５０ｍｇ制剂已经销售......
目的：了解基础状态动物模型肾局部ＲＡＳ的水平，观察其在用转换酶抑制剂（ＡＣＥＩ）和血管紧张素受体拮抗剂（ＡＴ１ＲＡ）干预治疗后的变化，探讨、比较这两种药物对肾......
目的 研究 L osartan对肾小球系膜细胞 (MCs)结缔组织生长因子 (CTGF)表达的影响。进一步探讨 L osartan延缓肾纤维化的机制。方......
肾素-血管紧张素-醛固酮系统(Renin-Angiotensh,RAAS)在维持正常人体内环境的平衡和在高血压、充血性心衰的病理生理过程中所起的......
Background Aortic dissection(AD)is a lethal medical emergency,which lacks specific biomarkers and ef-fective pharmaceuti......
建立氯沙坦及其活性代谢物E-3174在中国不同民族中的群体药代动力学模型,为临床个体化用药提供参考.采用HPLC荧光法同时测定氯沙坦......
